Publications

2026

  • Borges, A., Kokanov, S., Leitão, M. M., Ristić, P., Novaković, I., Dobričić, V., Nikolić, M., Zloh, M., Todorović, T., Simões, M., & Filipović, N. R. (2026). Novel pyridine-based thiazolyl-hydrazone as a promising attenuator of Pseudomonas aeruginosa pathogenicity by targeting quorum sensing. (In press).
  • Gonçalves, A. S., Leitão, M. M., Saavedra, M. J., Fernandes, J. R., Pereira, C., Simões, M., & Borges, A. (2026). Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa biofilms by a multifunctional triple combination of natural photosensitisers, gentamicin, and colistin. Microb. Pathog., 217, 108564.
  • Gonçalves, A. S., Leitão, M. M., Fernandes, J. R., Saavedra, M. J., Pereira, C., Simões, M., & Borges, A. (2026). Blue-light-activated berberine-gentamicin inhibits and eradicates Staphylococcus aureus biofilms by promoting oxidative stress and structural disruption. Bioorg. Chem., 178, 109931.
  • Gonçalves, A. S., Leitão, M. M., Simões, M., & Borges, A. (2026). Blue light-activated berberine-gentamicin combination breaks down biofilms in diabetic foot ulcers. J. Mater. Chem. B, 14, 4688–4703.
  • Leitão, M. M., Cagide, F., Gonçalves, A. S. C., Moreira, J., Fernandes, C., Borges, F., Simões, M., & Borges, A. (2026). Monoterpenoid-ciprofloxacin hybrids as a strategy to disrupt Staphylococcus aureus biofilms and overcome associated resistance. J. Adv. Res. (In press).
  • Massano, F., Afonso, A. C., Sousa, M., Teixeira, L. S., Borges, A., & Simões, M. (2026). The action of selected monoterpenes as biofilm control agents and antibiotic resistance modifiers. Biofouling, 42, 1–14.
  • Sousa, M., Borges, A., & Simões, M. (2026). Synergistic bactericidal effects of conventional biocides and phytochemicals for healthcare disinfection. J. Appl. Microbiol., 137(5).
  • Sousa, M., Borges, A., Sousa, S. F., & Simões, M. (2026). In vitro evaluation of the potentiating effects of plant-derived molecules on conventional biocides. J. Vis. Exp., 231.

2025

  • Gonçalves, A. S., Fernandes, J. R., Saavedra, M. J., Guimarães, N. M., Pereira, C., Simões, M., & Borges, A. (2025). New insights on antibacterial mode of action of blue-light photoactivated berberine and curcumin-antibiotic combinations against Staphylococcus aureus. Photodiagnosis Photodyn. Ther., 52, 104514.
  • Leitão, M. M., Gonçalves, A. S. C., Borges, F., Simões, M., & Borges, A. (2025). Polypharmacological strategies for infectious bacteria. Pharmacol. Rev., 77(2), 100038.
  • Leitão, M. M., Gonçalves, A. S. C., Sousa, S. F., Borges, F., Simões, M., & Borges, A. (2025). Two cinnamic acid derivatives as inhibitors of Pseudomonas aeruginosa las and pqs quorum-sensing systems: Impact on biofilm formation and virulence factors. Biomed. Pharmacother., 187, 118090.
  • Leitão, M. M., Gonçalves, A. S. C., Moreira, J., Fernandes, C., Borges, F., Simões, M., & Borges, A. (2025). Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Eur. J. Med. Chem., 283, 117163.
  • Nunes, B., Cagide, F., Borges, A., Borges, F., & Simões, M. (2025). Antibacterial effects of novel quaternary ammonium and phosphonium salts against Staphylococcus aureus. J. Appl. Microbiol., lxaf122.
  • Pérez-Lavalle, L., Borges, A., Gomes, I. B., Carrasco, E., Valero, A., & Simões, M. (2025). The ability of Salmonella enterica subsp. enterica strains to form biofilms on abiotic surfaces and their susceptibility to selected essential oil components. Lett. Appl. Microbiol., 78(3), ovaf032.
  • Sousa, M., Machado, I., Simões, L. C., & Simões, M. (2025). Biocides as drivers of antibiotic resistance: A critical review of environmental implications and public health risks. Environ. Sci. Ecotechnol., 25, 100557.

2024

  • Gonçalves, A. S., Leitão, M. M., Fernandes, J. R., Saavedra, M. J., Pereira, C., Simões, M., & Borges, A. (2024). Photodynamic activation of phytochemical-antibiotic combinations for combatting Staphylococcus aureus from acute wound infections. J. Photochem. Photobiol. B, 258, 112978.
  • Leitão, M. M., Vieira, T. F., Sousa, S. F., Borges, F., Simões, M., & Borges, A. (2024). Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibiotic efficacy for controlling Pseudomonas aeruginosa biofilms. Microb. Pathog., 191, 106663.

Conferences

2026

  • Afonso, A. (2026). Biofilmes e resistência antimicrobiana: do problema à inovação. Jornadas de Biomedicina, 13 May 2026, Universidade Fernando Pessoa, Porto, Portugal. Oral presentation.
  • Sousa, M., Borges, A., Sousa, S. F., & Simões, M. (2026). Phytochemicals as alternative strategies to traditional biocides for controlling bacterial biofilms in hospital disinfection. Eurobiofilms 2026, 17–20 June 2026, Guimarães, Portugal. Poster presentation.

2025

  • Borges, A. (2025). Phytochemicals in focus: Research approaches to controlling microbial communities. 2nd UPorto Research Summer School in Microbial Communities: Taste of PhD Experience, 7–8 July 2025, Porto, Portugal. Invited lecture.
  • Gonçalves, A. S. C., Borges, A., & Simões, M. (2025). Boosting antimicrobial photodynamic inactivation of Pseudomonas aeruginosa biofilms in chronic wounds with a colistin-berberine-gentamicin combination. FEMS MICRO Milan 2025, 14–17 July 2025, Milan, Italy. Oral presentation.
  • Gonçalves, A. S. C., Leitão, M. M., Simões, M., & Borges, A. (2025). Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa biofilms: A synergistic approach with berberine, gentamicin, and colistin. IV 1H-TOXRUN International Congress 2025 – No Boundaries for Toxicology: One Health, One Society, One Planet, 8–9 May 2025, Porto, Portugal. Poster presentation.
  • Gonçalves, A. S. C., Leitão, M. M., Simões, M., & Borges, A. (2025). Blue-light photoactivation of berberine-gentamicin combination: A synergistic strategy against Staphylococcus aureus acute wound infections. The 4th International Electronic Conference on Antibiotics: Challenges and Strategies for the Antibiotic Resistance Crisis, 21–23 May 2025, Online. Poster presentation.
  • Gonçalves, A. S. C., Simões, M., & Borges, A. (2025). Synergistic effects of berberine and gentamicin under blue light photoactivation against Staphylococcus aureus biofilms. DCE25 – 6th Doctoral Congress in Engineering, 30 June–1 July 2025, Porto, Portugal. Oral presentation.
  • Gonçalves, A. S. C., Simões, M., & Borges, A. (2025). Synergistic effects of blue-light activated berberine and gentamicin against dual-species biofilms of Pseudomonas aeruginosa and Staphylococcus aureus. 2nd UPorto Research Summer School in Microbial Communities: Taste of PhD Experience, 7–8 July 2025, Porto, Portugal. Oral presentation.
  • Leitão, M. M., Borges, F., Simões, M., & Borges, A. (2025). Disruption of quorum sensing in Pseudomonas aeruginosa by sinapic acid: Impacts on biofilm formation and virulence. The 4th International Electronic Conference on Antibiotics: Challenges and Strategies for the Antibiotic Resistance Crisis, 21–23 May 2025, Online. Oral presentation.
  • Leitão, M. M., Borges, F., Simões, M., & Borges, A. (2025). Targeting quorum sensing: Ferulic and sinapic acids compromise Pseudomonas aeruginosa biofilm architecture and virulence. IV 1H-TOXRUN International Congress 2025 – No Boundaries for Toxicology: One Health, One Society, One Planet, 8–9 May 2025, Porto, Portugal. Poster presentation.
  • Leitão, M. M., Simões, M., & Borges, A. (2025). Ferulic acid and sinapic acid attenuate Pseudomonas aeruginosa biofilm formation and virulence by targeting the pqs quorum sensing system. Biofilms 11 – Interdisciplinary Momentum: Accelerating Biofilm Research and Innovation Across Boundaries, 13–15 May 2025, Cardiff, United Kingdom. Oral presentation.
  • Massano, F., Sousa, M., Borges, A., & Simões, M. (2025). Selected monoterpenes as potential biofilm control agents and antibiotic resistance modifiers. DCE25 – 6th Doctoral Congress in Engineering, 30 June–1 July 2025, Porto, Portugal. Oral presentation.
  • Sousa, M., Borges, A., & Simões, M. (2025). Development of new phytochemical-based disinfectant formulations for the control of healthcare-associated bacterial infections. IV 1H-TOXRUN International Congress 2025 – No Boundaries for Toxicology: One Health, One Society, One Planet, 8–9 May 2025, Porto, Portugal. Oral presentation.
  • Teixeira, L. S., Fraga, S., Simões, M., & Borges, A. (2025). Combinations of riboflavin with antiseptics for tackling methicillin-resistant Staphylococcus aureus infections by photodynamic inactivation. The 4th International Electronic Conference on Antibiotics: Challenges and Strategies for the Antibiotic Resistance Crisis, 21–23 May 2025, Online. Poster presentation.
  • Teixeira, L. S., Fraga, S., Simões, M., & Borges, A. (2025). Harmine-antiseptic dual combination photodynamic therapy for targeting methicillin-resistant Staphylococcus aureus. DCE25 – 6th Doctoral Congress in Engineering, 30 June–1 July 2025, Porto, Portugal. Poster presentation.
  • Teixeira, L. S., Fraga, S., Simões, M., & Borges, A. (2025). Photodynamic inactivation of methicillin-resistant Staphylococcus aureus using harmine-antiseptic combinations. IV 1H-TOXRUN International Congress 2025 – No Boundaries for Toxicology: One Health, One Society, One Planet, 8–9 May 2025, Porto, Portugal. Poster presentation.

Special Issues

Sustainable Innovation in Antibiotic Adjuvants: Developing Strategies to Overcome Antibiotic Resistance and Biofilm Infections. Antibiotics (ISSN 2079-6382). Editors: Dr. Ana Afonso, Dr. Anabela Borges